The toolbox will include separation processes based on extraction, pervaporation, adsorption, absorption and membrane technology. The following main results are expected to be obtained: 1) New and existing building blocks of a miniaturised downstream processing toolbox will be developed, standardized and evaluated. The main objective of this project is to establish a microscale downstream processing toolbox which can be used for rapid and high content screening or for process development. The more rapidly such an investigation can be conducted, the faster critical decisions about economical feasibility of a bio-based process can be taken, and the faster one can bring a product on the market. Consequently, a series of separation process candidates have to be investigated with the purpose of achieving the most efficient downstream processing configuration. The economical feasibility of a bio-based process is typically dependent to a large extent on the efficiency and the cost of the subsequent separation steps. However, the reaction step of such a biocatalysis process needs to be integrated with one or several purification steps to recover products and/or remove inhibitory substances. Such an improvement in yield should make biocatalysis an even greener process and make it also economically more viable.īiocatalysis can replace traditional chemical catalysis based procesess resulting in a greener production process. We will then use this information to determine how larger systems (ie the systems where the products will effectively be produced and purified) should be designed to improve their yield. an organic one), and under what conditions they do so best, in a process that is called liquid-liquid extraction. We envisage for example to study the effects of how product molecules 'transition' from one solvent (e.g. Miniaturisation will also mean that particular effects can be studied with greater detail. Miniaturisation will mean a more cost-effective use of resources to undertake the investigations. Here, we propose to use the advances in microfabrication to create miniaturised devices which can mimic the larger ones typically used for purification, so that the different steps can be evaluated more rapidly. The more rapidly such an investigation can be conducted, the faster critical decisions about the economic viability can be taken, and the faster one can bring a product to the market. To rapidly understand the process and operating conditions of these purification steps - which in turn determines the cost and viability of the whole process - it is necessary to rapidly analyse different purification step 'candidates' and select the most efficient one(s). And it is often the cost of these purification steps which determine the economic viability of such a biocatalytic process. This typically requires several purification steps. the steps where the desired product is produced, but also those steps where the desired product is separated from by-products and residual (i.e. To fully harness the advantages of this technology, it is necessary to understand not only the reaction steps, i.e. Biocatalysis uses enzymes to enable greener production process.
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